Glucose Tolerance & Insulin Sensitivy

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Glucose tolerance and insulin sensitivity tests can also be built into the test design. An intravenous glucose tolerance test measures the blood glucose levels following an intravenous bolus of dextrose in a fasted dog and is a measure of glucose intolerance. The figure below shows intravenous glucose tolerance data from lean and obese dogs. This basic test can be modified in a number of ways to determine insulin resistance. The insulin sensitivity index can be calculated based on insulin assay at the same time as the glucose determinations. The classical gold standard test used to determine insulin sensitivity is the hyperinsulinaemic euglycemic clamp technique. Alternatively, the frequently sampled intravenous glucose tolerance test has been used to quantify insulin sensitivity in the dog.