Neurobiological Endpoint Assessment

CanCog can arrange for the following screens to be used in conjunction with cognitive or behavioral screens to assess neurobiological endpoints.

Histological Screens

• Stereological assessment of cell counts and cell density
• Structure-specific analysis of beta-amyloid load. Quantitative analysis of soluble and insoluble beta-amyloid, and amyloid precursor protein.
• Tyrosine hydroxylase
• Neuroinflammation
• Neurogenesis

Neurophysiological Screens

• EEG activity from cortical and depth electrodes
• Sensory and electrically evoked potentials
• EMGs
• Recordings of seizure activity

Other Procedures

• CSF samples
• Electrode implantation for brain recording studies
• Biopsies
• Serum / plasma sampling (serial sampling)
• Additional protocols available upon request.